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NUCLEAR RECEPTORS, ROS & CANCER BIOLOGY

WONG CHEW HOOI BSc.(Hon) NGS Postgraduate student Department of Physiology MD9, 2 Medical Drive Email: g0501804@nus.edu.sg Major Supervisor: Prof. Shazib Pervaiz TAC Member and Mentor: Dr. Alan Prem Kumar Tel: (65) 6516-3229 Fax: (65) 6778-8161

Previously, classical programmed cell death has been exemplified by apoptosis, as it is a highly regulated and controlled form of cell death. However, more recent evidence indicates that programmed cell death is not exclusively confined to apoptosis. To that end, autophagy has been demonstrated as an alternative form of cell death; identified as Type II cell death in addition to the classical Type I apoptotic cell death. Despite the extensive studies under way, the exact mechanism of autophagy-induced cell death and the signaling pathways involved have not been fully established. JNK, a member of the MAP Kinase family has been implicated in autophagy. We are interested in identifying the role of JNK activation in the induction of autophagy. Furthermore, we aim to resolve the question of whether autophagy is an important cell death mechanism.